تفاعل #53928

معادلة التفاعل

trans-[4-(5-Bromo-pentyl)-cyclohexyl]-carbamic acid tert-butyl ester

MeOH

HBr

MeOH

acetylbromide

→

trans-4-(5-Bromo-pentyl)-cyclohexylamine

المردود 129.2%

المذيبات

toluene

ظروف التفاعل

المعالجة

1. 1
   أخرىAt 0° C.
2. 2
   أخرىevaporated (2×)
3. 3
   درجة الحرارةcooled (−10 to −15° C.)
4. 4
   ترشيحfiltered

الإجراء التجريبي

At 0° C., a solution of 4.4 g (12.63 mmol) of trans-[4-(5-Bromo-pentyl)-cyclohexyl]-carbamic acid tert-butyl ester were received in 9 m MeOH was added to 40 ml of a HBr solution in MeOH (made by dropping at 0° C., 4.7 ml (63.07 mmol) of acetylbromide to 35 ml MeOH). The suspension was stirred for 16 h at RT, diluted with toluene and evaporated (2×). The residue was suspended in EtOAc (40 ml) cooled (−10 to −15° C.) and filtered to give 4.05 g (97%) of trans-4-(5-Bromo-pentyl)-cyclohexylamine as hydrobromide salt, MS: 248 (MH+, 1Br).

المصدر