تفاعل #53870

ord-5f96f3eaf2ac40319f944851794fe16c

معادلة التفاعل

O=C(Cl)C(=O)Cl
oxalylchloride
O=C=O
dry-ice
CS(C)=O
DMSO
CN(C(=O)OC(C)(C)C)[C@H]1CC[C@H](CCC=O)CC1
trans-Methyl-[4-(3-oxo-propyl)-cyclohexyl]-carbamic acid tert-butyl ester
CCOC(=O)CP(=O)(OCC)OCC
triethyl phosphono acetate
CN(C(=O)OC(C)(C)C)[C@H]1CC[C@H](CCCO)CC1
trans-[4-(3-Hydroxy-propyl)-cyclohexyl]-methyl-carbamic acid tert-butyl ester
C[O-].[Na+]
NaOMe
CCN(CC)CC
Et3N
CCOC(=O)C=CCC[C@H]1CC[C@H](N(C)C(=O)OC(C)(C)C)CC1
trans-5-[4-(tert-Butoxycarbonyl-methyl-amino)-cyclohexyl]-pent-2-enoic acid ethyl ester
المردود 58.0%

المذيبات

ظروف التفاعل

درجة الحرارة
-78°CELSIUS
الظروف التفصيلية
See reaction.notes.procedure_details.

المعالجة

  1. 1
    workup.ADDITIONwas added
  2. 2
    أخرىto attain RT
  3. 3
    غسيلwashed with 1N HCl and water
  4. 4
    أخرىAfter evaporation of the solvents
  5. 5
    workup.STIRRINGThe solution was stirred for 20 h at RT
  6. 6
    تركيزconcentrated in vacuo
  7. 7
    workup.DISSOLUTIONThe crude residue was dissolved in Et2O
  8. 8
    غسيلwashed with water
  9. 9
    تركيزThe organic layers were concentrated in vacuo
  10. 10
    أخرىthe crude product purified by chromatography on silica gel with EtOAc/Hexane 1:4

الإجراء التجريبي

1.4 ml (16.24 mmol) oxalylchloride was added to a dry-ice cooled solution (−78° C.) of 1.78 ml (25 mmol) DMSO in 40 ml CH2Cl2. After 10 min. stirring at −78° C., 2.39 g (12.49 mmol) of trans-[4-(3-Hydroxy-propyl)-cyclohexyl]-methyl-carbamic acid tert-butyl ester, dissolved in 5 ml CH2Cl2, was added. 15 min later, 8.7 ml (62.4 mmol) Et3N was added and the reaction-mixture was allowed to attain RT. The mixture was diluted with Et2O and then washed with 1N HCl and water. After evaporation of the solvents, a solution of crude trans-Methyl-[4-(3-oxo-propyl)-cyclohexyl]-carbamic acid tert-butyl ester (3.24 g, 12.02 mmol) and of 2.73 ml (13.3 mmol) triethyl phosphono acetate in 30 ml ethanol, was treated under ice-cooling with 1.37 g (24.05 mmol) NaOMe. The solution was stirred for 20 h at RT, and then concentrated in vacuo. The crude residue was dissolved in Et2O and washed with water. The organic layers were concentrated in vacuo and the crude product purified by chromatography on silica gel with EtOAc/Hexane 1:4 to yield 2.46 g (58%, 2 steps) of clean trans-5-[4-(tert-Butoxycarbonyl-methyl-amino)-cyclohexyl]-pent-2-enoic acid ethyl ester, MS: 339 (M).

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US06858651B2uspto-grants-2005_02