تفاعل #53853

معادلة التفاعل

trans-4-tert-Butoxycarbonylamino-cyclohexanecarboxylic acid

N,O-dimethyl-hydroxylamine hydrochloride

N-methylmorpholine

EDCI

HOBT

→

trans-[4-(Methoxy-methyl-carbamoyl)-cyclohexyl]-carbamic acid tert-butyl ester

المردود 103.0%

المذيبات

CH2Cl2

ظروف التفاعل

المعالجة

1. 1
   استخلاصextracted with aqueous 10% KHSO4/Et2O (3×)
2. 2
   غسيلThe organic phases were washed with aqueous saturated NaHCO3, 10% NaCl
3. 3
   تجفيفdried over Na2SO4

الإجراء التجريبي

A solution of 20 g (82.2 mmol) trans-4-tert-Butoxycarbonylamino-cyclohexanecarboxylic acid in 1.2 l CH2Cl2 was treated with 12.83 g (131.5 mmol) N,O-dimethyl-hydroxylamine hydrochloride, 10.85 ml (98.6 mmol) N-methylmorpholine and at 0° C. with 18.91 g (98.64 mmol) EDCI and 12.62 g (82.2 mmol) HOBT. The reaction mixture was stirred 2 h at room temperature and extracted with aqueous 10% KHSO4/Et2O (3×). The organic phases were washed with aqueous saturated NaHCO3, 10% NaCl and dried over Na2SO4 to yield 24.25 g (quantitative) trans-[4-(Methoxy-methyl-carbamoyl)-cyclohexyl]-carbamic acid tert-butyl ester, mp: 130-140° C., slowly dec.; MS: 287 (MH+).

المصدر