تفاعل #53827

ord-a584e4b6814b45f3af7898c90f99d6fa

معادلة التفاعل

CN([C@H]1CC[C@H](O)CC1)S(=O)(=O)c1ccc(Br)cc1
trans-4-Bromo-N-(4-hydroxy-cyclohexyl)-N-methyl-benzenesulfonamide
BrCCCCCCBr
1,6-dibromohexane
→
CN([C@H]1CC[C@H](OCCCCCCBr)CC1)S(=O)(=O)c1ccc(Br)cc1
trans-4-Bromo-N-[4-(6-bromo-hexyloxy)-cyclohexyl]-N-methyl-benzenesulfonamide

المتفاعلات

CN([C@H]1CC[C@H](O)CC1)S(=O)(=O)c1ccc(Br)cc1
trans-4-Bromo-N-(4-hydroxy-cyclohexyl)-N-methyl-benzenesulfonamide
BrCCCCCCBr
1,6-dibromohexane

الكواشف

لا شيء

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

الإجراء التجريبي

In analogy to example 11.11, trans-4-Bromo-N-(4-hydroxy-cyclohexyl)-N-methyl-benzenesulfonamide and 1,6-dibromohexane were reacted to yield trans-4-Bromo-N-[4-(6-bromo-hexyloxy)-cyclohexyl]-N-methyl-benzenesulfonamide as off-white solid, MS: 510 (MH+, 1Br).

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US06858651B2uspto-grants-2005_02