تفاعل #5380

معادلة التفاعل

2-(6-hydroxy-2-naphthyl)-5-butylbenzooxazole

octyl iodide

potassium hydroxide

butanol

→

2-(6-octyloxy-2-naphthyl)-5-butylbenzooxazole

المردود 56.6%

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةby refluxing for 310 minutes
2. 2
   استخلاصextracted from ethyl acetate
3. 3
   أخرىto obtain an organic layer
4. 4
   غسيلThe organic layer was washed with water
5. 5
   تجفيفdried with mirabilite
6. 6
   أخرىdried under reduced pressure
7. 7
   أخرىto obtain a resultant
8. 8
   أخرىThe resultant was recrystallized from ethylacetate
9. 9
   أخرىto obtain a crystal
10. 10
    ترشيحThe crystal was filtered
11. 11
    أخرىpurified by silica gel column chromatography (eluent: toluene)
12. 12
    أخرىrecrystallized from acetone

الإجراء التجريبي

In a 30ml round-bottom flask, 0.47 g (1.48 m mole) of 2-(6-hydroxy-2-naphthyl)-5-butylbenzooxazole, 0.43 g (1.79 m mole) of octyl iodide, 0.12 g (1.82 m mole) of potassium hydroxide and 5 ml of butanol were placed, followed by refluxing for 310 minutes. The reaction mixture was poured into water, extracted from ethyl acetate to obtain an organic layer. The organic layer was washed with water dried with mirabilite and dried under reduced pressure to obtain a resultant. The resultant was recrystallized from ethylacetate to obtain a crystal. The crystal was filtered, purified by silica gel column chromatography (eluent: toluene) and recrystallized from acetone to obtain 0.36 g of 2-(6-octyloxy-2-naphthyl)-5-butylbenzooxazole (Yield: 56.6%). ##STR190##

المصدر