تفاعل #53798

معادلة التفاعل

product

5-(5,6-Difluoro-1H-indol-2-yl)-2-methoxy-phenyl isothiocyanate

5-(5,6-difluoro-1H-indol-2-yl)-2-methoxy-phenyl isothiocyanate

serine tert-butylether tert-butylester

→

(S)-3-tert-Butoxy-2-{3-[5-(5,6-Difluoro-1H-indol-2-yl)-2-methoxy-phenyl]-thioureido}-propionic acid tert-butyl ester

ظروف التفاعل

المعالجة

1. 1
   أخرىto give the product
2. 2
   ترشيحafter filtration through silica gel

الإجراء التجريبي

The product from Example 35, Step A, 5-(5,6-difluoro-1H-indol-2-yl)-2-methoxy-phenyl isothiocyanate (0.316 g, 1.0 mmol) was reacted with serine tert-butylether tert-butylester (0.226 g, 1.0 mmol) according to the procedure for Example 23, Step B to give the product after filtration through silica gel using hexanes/ethyl acetate, 1/1, v/v as eluant (0.377 g in 2 portions), mp 111-114° C.

المصدر