تفاعل #53796

معادلة التفاعل

product

5-(1H-Indol-2-yl)-2-methoxy-phenylamine

5-(1H-indol-2-yl)-2-methoxy-phenylamine

4-carboxyphenyl isothiocyanate

→

product

4-{3-[5-(1H-Indol-2-yl)-2-methoxy-phenyl]-thioureido}-benzoic acid

المذيبات

tetrahydrofuran

ظروف التفاعل

المعالجة

1. 1
   أخرىThe solvent was boiled off on the rotary evaporator (no vacuum), and ethyl acetate
2. 2
   workup.ADDITIONwas added to the residue
3. 3
   ترشيحthe insoluble material was collected by filtration
4. 4
   تركيزconcentrated to dryness
5. 5
   أخرىtriturated again with ethyl acetate

الإجراء التجريبي

The product from Example 1, Step B, 5-(1H-indol-2-yl)-2-methoxy-phenylamine (0.286 g, 1.0 mmol) was mixed with 4-carboxyphenyl isothiocyanate (0.185 g, 1.03 mmol) in tetrahydrofuran (40 mL). The solvent was boiled off on the rotary evaporator (no vacuum), and ethyl acetate was added to the residue and the insoluble material was collected by filtration. The collected solid was taken up in tetrahydrofuran, concentrated to dryness, and triturated again with ethyl acetate to give the product as a white solid (0.180 g), mp 201-203° C.

المصدر