تفاعل #53786

معادلة التفاعل

HCl

1-Dodecanesulfonyl chloride

5-(5,6-difluoro-1H-indol-2-yl)-2-methoxy-phenyl-amine

5-(5,6-Difluoro-1H-indol-2-yl)-2-methoxy-phenylamine

water

→

product

المردود 44.9%

Dodecane-1-sulfonic acid [5-(5,6-difluoro-1H-indol-2-yl)-methoxy-phenyl]-amide

المردود 44.9%

المذيبات

pyridine

ظروف التفاعل

المعالجة

1. 1
   ترشيحAfter several hours the precipitate was filtered off
2. 2
   غسيلrinsed three times with water
3. 3
   أخرىdried
4. 4
   أخرىRecrystallization from ethanol

الإجراء التجريبي

1-Dodecanesulfonyl chloride (0.3 g, 1.1 mmol) was added to a stirred solution of 5-(5,6-difluoro-1H-indol-2-yl)-2-methoxy-phenyl-amine from Example 3 (0.3 g, 1.11 mmol) in pyridine (3 mL) under an inert atmosphere at room temperature. After approximately 20 hours the mixture was poured into water (30 mL), stirred, and acidified with aqueous HCl. After several hours the precipitate was filtered off, rinsed three times with water, and dried. Recrystallization from ethanol afforded the product (0.25 g), mp 148-149° C.

المصدر