تفاعل #53718

معادلة التفاعل

di-tert-butyl dicarbonate

tert-Butyl 3-iodo-5-(N-tert-butoxycarbonyl-2-thiophenesulfonylamino)-indazolecarboxylate

5-amino-3-iodo-1H-indazole

thiophene-2-sulfonyl chloride

→

solid

{N-[3-(1H-indol-2-yl)-1H-indazol-5-yl]}thiophene-2-sulfonamide

ظروف التفاعل

المعالجة

1. 1
   أخرىThe intermediate crude is purified by flash chromatography (98/2 by volume dichloromethane/methanol)
2. 2
   أخرىresulting in 2.30 g of an orangey solid, which
3. 3
   أخرىAfter purification by flash chromatography (eluent:dichloromethane), 3.15 g of tert-butyl 3-iodo-5-(N-tert-butoxycarbonyl-2-thiophenesulfonylamino)indazolecarboxylate

الإجراء التجريبي

tert-Butyl 3-iodo-5-(N-tert-butoxycarbonyl-2-thiophenesulfonylamino)-indazolecarboxylate can be prepared as described in Example 85 using 2 g of 5-amino-3-iodo-1H-indazole and 1.61 g of thiophene-2-sulfonyl chloride. The intermediate crude is purified by flash chromatography (98/2 by volume dichloromethane/methanol), resulting in 2.30 g of an orangey solid, which is then treated with 3.71 g of di-tert-butyl dicarbonate according to the procedure. After purification by flash chromatography (eluent:dichloromethane), 3.15 g of tert-butyl 3-iodo-5-(N-tert-butoxycarbonyl-2-thiophenesulfonylamino)indazolecarboxylate are obtained in the form of a white solid melting at 163° C. (LC/MS analysis: Tr=4.34 minutes; [M+H]+=605.93; [M+H]+-tert-butyl=549.90).

المصدر