تفاعل #535922
ord-e1f7a8fffb6b4bdbbec4704afa3884a5
معادلة التفاعل
4-fluorobenzoyl chloride
1-aminocyclohexanecarboxylic acid
sodium carbonate
→
title compound
1-[(4-Fluorobenzoyl)amino]cyclohexanecarboxylic acid
الكواشف
لا شيء
ظروف التفاعل
الظروف التفصيلية
See reaction.notes.procedure_details.
المعالجة
- 1درجة الحرارةUnder ice-cooling
- 2أخرىAfter the ether layer was separated
- 3درجة الحرارةcooling
- 4ترشيحthe precipitated crystal was collected by filtration
الإجراء التجريبي
Under ice-cooling, a solution of 25.0 g (15.8 mmol) of 4-fluorobenzoyl chloride in 30 ml of ether was added dropwise to a mixture solution of 22.6 g (15.8 mmol) of 1-aminocyclohexanecarboxylic acid and 25.0 g (23.7 mmol) of sodium carbonate in 100 ml of ether and 300 ml of water, and the mixture was stirred at room temperature overnight. After the ether layer was separated, the aqueous layer was neutralized by concentrated hydrochloric acid under ice-cooling, and the precipitated crystal was collected by filtration to obtain 27.7 g (66%) of the title compound.