تفاعل #535921

معادلة التفاعل

Ethyl acetate

1-aminocyclohexanecarboxylic acid

triethylamine

dimethylformamide

→

title compound

المردود 60.0%

1-[[(2-Oxo-2H-pyran-5-yl)carbonyl]amino]cyclohexanecarboxylic acid

المردود 60.0%

ظروف التفاعل

المعالجة

1. 1
   غسيلthe mixture was washed with a 10% aqueous potassium hydrogensulfate solution
2. 2
   تجفيفAfter it was dried with anhydrous sodium sulfate
3. 3
   workup.DISTILLATIONthe solvent was distilled off under reduced pressure

الإجراء التجريبي

2.37 g (10 mmol) of 5-coumarinecarboxylic acid N-hydroxysuccinimide ester and a solution of 1.43 g (10 mmol) of 1-aminocyclohexanecarboxylic acid and 3.04 g (30 mmol) of triethylamine in 20 ml of dimethylformamide were stirred overnight. Ethyl acetate was added to the reaction solution, and the mixture was washed with a 10% aqueous potassium hydrogensulfate solution and then saturated brine. After it was dried with anhydrous sodium sulfate, the solvent was distilled off under reduced pressure to obtain 1.42 g (60%) of the title compound.

المصدر