تفاعل #534358

ord-687063cbc1674a448e4a228f4346c316

معادلة التفاعل

Cc1nc(CO)cn1-c1ccc(F)cc1
[1-(4-Fluoro-phenyl)-2-methyl-1H-imidazol-4-yl]-methanol
Cc1nc(C=O)cn1-c1ccc(F)cc1
(4-fluoro-phenyl)-2-methyl-1H-imidazole-4-carbaldehyde

المذيبات

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

المعالجة

  1. 1
    ترشيحThe suspension is filtered through a dicalite speed plus pad

الإجراء التجريبي

[1-(4-Fluoro-phenyl)-2-methyl-1H-imidazol-4-yl]-methanol is dissolved in methylene chloride. Mangan (IV) oxide is added and the reaction mixture is stirred at room temperature for 3 days. The suspension is filtered through a dicalite speed plus pad and the desired compound (4-fluoro-phenyl)-2-methyl-1H-imidazole-4-carbaldehyde is obtained.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US08481548B2uspto-grants-2013_07