تفاعل #5337

معادلة التفاعل

syrup

Methyl 3-amino-2-[[2'-(ethoxycarbonyloxycarbamimidoyl)biphenyl-4-yl]methylamino]benzoate

tetraethoxymethane

acetic acid

→

title compound

Methyl 2-ethoxy-1-[[2'-(ethoxycarbonyloxy-carbamimidoyl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate

المذيبات

dioxane

ظروف التفاعل

المعالجة

1. 1
   تركيزThe reaction mixture was concentrated to dryness
2. 2
   أخرىThe residue was crystallized from ethyl acetate (50 ml)
3. 3
   أخرىResulting crystalline precipitates
4. 4
   ترشيحwere collected by filtration

الإجراء التجريبي

The pale brown syrup (8.58 g) obtained in Example (57a) was dissolved in dioxane (20 ml). To the solution were added tetraethoxymethane (8.64 g) and acetic acid (1.56 g). The mixture was stirred for 2 hours at 100° C. The reaction mixture was concentrated to dryness. The residue was crystallized from ethyl acetate (50 ml). Resulting crystalline precipitates were collected by filtration to obtain the title compound.

المصدر