تفاعل #53350
ord-88e5633eab164bc19133f4639fe81750
معادلة التفاعل
starting material XVIII
(±)-8-Methyl-5-(4-nitrophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine-7-carbothiohydrazide
triethyl orthoformate
hydrochloric acid
→
title compound
المردود 77.0%
(±)-8-Methyl-5-(4-nitrophenyl)-7-(1,3,4-thiadiazol-2-yl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine
المردود 77.0%
المتفاعلات
الكواشف
لا شيء
ظروف التفاعل
الظروف التفصيلية
See reaction.notes.procedure_details.
المعالجة
- 1درجة الحرارةAfter cooling the precipitated crystals
- 2ترشيحwere filtered off
- 3غسيلwashed with ethanol
- 4أخرىdried
الإجراء التجريبي
A mixture of 0.57 g (1.43 mmol) of the starting material XVIII, 6 ml of triethyl orthoformate and a catalytic amount of hydrochloric acid was stirred at 80° C. for 1 h. After cooling the precipitated crystals were filtered off, washed with ethanol and dried to yield 0.45 g (77%) of the title compound; Mp.: 212-213° C.