تفاعل #53340

معادلة التفاعل

compound XVIII

(±)-8-Methyl-5-(4-nitrophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine-7-carbothiohydrazide

chloroform

methyl isocyanate

→

(±)-1-{8-Methyl-5-(4-nitrophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine-7-carbothioyl}-4-methyl-semicarbazide

المردود 88.0%

ظروف التفاعل

المعالجة

1. 1
   غسيلAfter 1 h the reaction mixture was washed with sodium hydrogen carbonate solution and water
2. 2
   تركيزafter concentration the obtained solid material
3. 3
   أخرىwas purified
4. 4
   درجة الحرارةby refluxing in ethanol

الإجراء التجريبي

To a stirred solution of 0.40 g (1.0 mmol) of compound XVIII in 15 ml of chloroform 0.07 ml (1.2 mmol) of methyl isocyanate was added. After 1 h the reaction mixture was washed with sodium hydrogen carbonate solution and water and after concentration the obtained solid material was purified by refluxing in ethanol. The desired product was 0.36 g, yield: 88%. Mp.: 200° C.

المصدر