تفاعل #5333

معادلة التفاعل

methyl 3-iodobenzoate

toluene

→

title compound

المردود 29.0%

Methyl 4'-methylbiphenyl-3-carboxylate

المردود 29.0%

المذيبات

4-iodotoluene

ظروف التفاعل

المعالجة

1. 1
   ترشيحInsoluble materials were filtered off
2. 2
   تركيزthe filtrate was concentrated to dryness
3. 3
   أخرىThe residue was purified by column chromatography on silica gel

الإجراء التجريبي

To a mixture of methyl 3-iodobenzoate (26.1 g) in 4-iodotoluene (21.9 g) was added copper powder (31.8 g) gradually at 180°-190° C. The mixture was then stirred for 6 hours at 200°-210° C. The reaction mixture was cooled to room temperature, to which was added toluene. Insoluble materials were filtered off, and the filtrate was concentrated to dryness. The residue was purified by column chromatography on silica gel to afford the title compound as a colorless oil (6.61 g, 29%).

المصدر