تفاعل #53321

معادلة التفاعل

Iodomethane

4-cyanophenyl-thiourea

→

methyl N′-(4-cyanophenyl)-carbamimidothioate

المردود 84.0%

المذيبات

acetone

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe precipitate was filtered off
2. 2
   أخرىdried
3. 3
   workup.DISSOLUTIONdissolved in DCM
4. 4
   غسيلThe organic solution was washed with NH3 (aq.) (excess)
5. 5
   تجفيفdried with potassium carbonate
6. 6
   ترشيحfiltered
7. 7
   أخرىthe solvent was evaporated

الإجراء التجريبي

Iodomethane (1.76 ml) was added to 4-cyanophenyl-thiourea (5.0 g) in acetone (100 ml). The reaction mixture was stirred overnight at RT. The precipitate was filtered off, dried and dissolved in DCM. The organic solution was washed with NH3 (aq.) (excess), dried with potassium carbonate, filtered, and the solvent was evaporated, yielding 4.53 g (84%, white solid) of methyl N′-(4-cyanophenyl)-carbamimidothioate (intermediate 6).

المصدر