تفاعل #53320

معادلة التفاعل

1-(4-pyridyl)-4-piperidone

nitromethane

sodium

→

title compound

4-hydroxy-4-nitromethyl-1-(4-pyridyl)piperidine

المذيبات

methanol

methanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةcooled temperature
2. 2
   درجة الحرارةcooled temperature for 10 minutes
3. 3
   ترشيحThe precipitate was filtered
4. 4
   غسيلwashed with methanol

الإجراء التجريبي

To a solution of nitromethane (2.31 ml) in methanol (5.4 ml) was added sodium (70 mg) at ice-cooled temperature. The resulting mixture was added dropwise to a solution of 1-(4-pyridyl)-4-piperidone (5.36 g) in methanol (10.7 ml) at ice-cooled temperature for 10 minutes, and stirred for 15 hours at room temperature. The precipitate was filtered, and washed with methanol to obtain the title compound (5.31 g).

المصدر