تفاعل #53241

معادلة التفاعل

guanidine carbonate

ethyl acetoacetate

→

6-methyl-iso cytosine

المردود 125.6%

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe reaction solution was gradually heated
2. 2
   درجة الحرارةto reflux temperature
3. 3
   أخرىEthanol (300 mL) was evaporated
4. 4
   درجة الحرارةthe reaction mixture was heated
5. 5
   درجة الحرارةunder reflux for two hours
6. 6
   درجة الحرارةAfter the reaction mixture was cooled
7. 7
   workup.ADDITION300 mL of hexane was added
8. 8
   ترشيحThe resulting precipitate was filtered
9. 9
   غسيلwashed
10. 10
    أخرىdried

الإجراء التجريبي

Dry ethanol (600 mL), 91.89 g of guanidine carbonate, and 146.1 g of ethyl acetoacetate were added to a 1 L flask. The reaction solution was gradually heated to reflux temperature and stirred overnight. Ethanol (300 mL) was evaporated, and the reaction mixture was heated under reflux for two hours. After the reaction mixture was cooled, 300 mL of hexane was added. The resulting precipitate was filtered, washed and dried. 119.3 g of 6-methyl-iso cytosine was obtained.

المصدر