تفاعل #53211

معادلة التفاعل

dimethylamine

4-[3-(p-tolylsulphonyloxy)-prop-1-ynyl]-nitrobenzene

→

4-(3-dimethylaminoprop-1-ynyl)-nitrobenzene

المذيبات

dichloromethane

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   غسيلThen the reaction solution is washed with water
2. 2
   أخرىThe residue is chromatographed on silica gel (dichloromethane/methanol=10:1)
3. 3
   أخرىThe product is obtained as an oil

الإجراء التجريبي

190 ml (4.2 mmol) of dimethylamine dissolved in 2.5 ml of dichloromethane are added dropwise at 0° C. to a solution of 0.7 g (2.1 mmol) of 4-[3-(p-tolylsulphonyloxy)-prop-1-ynyl]-nitrobenzene in 10 ml of dichloromethane. The cooling is stopped and the mixture is stirred for 18 hours at ambient temperature. Then the reaction solution is washed with water and freed from solvent. The residue is chromatographed on silica gel (dichloromethane/methanol=10:1). The product is obtained as an oil.

المصدر