تفاعل #53198

معادلة التفاعل

methylamine

4-(2-bromoethyl)-nitrobenzene

hydrochloric acid

→

4-(2-methylamino-ethyl)-nitrobenzene

المذيبات

dichloromethane

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwhile cooling with ice
2. 2
   أخرىto come up slowly to ambient temperature
3. 3
   غسيلthe mixture is washed with dichloromethane
4. 4
   استخلاصthe product is extracted with dichloromethane

الإجراء التجريبي

2.7 g (86 mmol) of methylamine are dissolved in 120 ml of dichloromethane while cooling with ice. 4.9 g (21 mmol) of 4-(2-bromoethyl)-nitrobenzene are added and the mixture is allowed to come up slowly to ambient temperature. After 15 hours stirring the solvent is eliminated in vacuo and the residue taken up in water. An acid pH is created using 2 N hydrochloric acid and the mixture is washed with dichloromethane. The aqueous phase is then adjusted to a basic pH using 4 N sodium hydroxide solution and the product is extracted with dichloromethane.

المصدر