تفاعل #531857

معادلة التفاعل

4-(3-adamantan-1-yl-ureido)butyric acid

K2CO3

iodomethane

→

883

المردود 95.0%

4-(3-Adamantan-1-yl-ureido) butyric Acid Methyl Ester

المردود 95.0%

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   استخلاصThen the product was extracted with ether (20 mL)
2. 2
   غسيلthe ether was washed with 1 N NaOH aqueous solution (20 mL) and brine (20 mL)
3. 3
   تجفيفdried over Na2SO4
4. 4
   أخرىevaporated

الإجراء التجريبي

A mixture of 4-(3-adamantan-1-yl-ureido)butyric acid 822 (0.15 g, 0.54 mmol), K2CO3 (0.09 g, 0.64 mmol), and iodomethane (0.04 mL, 0.59 mmol) in DMF (20 mL) was stirred at room temperature for 20 h. Then the product was extracted with ether (20 mL), and the ether was washed with 1 N NaOH aqueous solution (20 mL) and brine (20 mL), dried over Na2SO4, and evaporated to afford 0.15 g (95%) of 883: 1H NMR (CDCl3) 1.66-1.68 (6H, m), 1.81 (2H, quint, J=6.9 Hz), 1.94-1.97 (6H, m), 2.05-2.07 (3H, m), 2.37 (2H, t, J=6.9 Hz), 3.16 (2H, q, J=6.9 Hz), 3.68 (3H, s), 4.09 (1H, s), 4.25 (1H, s); LC-MS (ESI) m/z calcd for C16H26N2O3 [M+H]+ 295.19. found [M+H]+ 295.24; mp 114 C. Anal. (C16H26N2O3) C, H, N.

المصدر