تفاعل #531804

معادلة التفاعل

Acetic acid

4-pentynoic acid

N-hydroxy succinimide

DCC

→

10a

المردود 100.5%

Pent-4-ynoic acid 2,5-dioxo-pyrrolidin-1-yl ester

المردود 100.5%

المذيبات

THF

ظروف التفاعل

المعالجة

1. 1
   workup.WAITthen left
2. 2
   workup.STIRRINGto stir at room temperature overnight
3. 3
   workup.WAIT(A white precipitate was observed after 15 min
4. 4
   أخرىThe resulting DCU was removed by filtration
5. 5
   أخرىThe filtrate was then evaporated

الإجراء التجريبي

4-pentynoic acid (5.0 g, 51 mmol) and N-hydroxy succinimide (5.87 g, 51 mmol) were added to a solution of DCC (12.6 g, 61.2 mmol) in THF (125 ml) at −10° C. The mixture was then stirred for 1 h at −10° C. then left to stir at room temperature overnight. (A white precipitate was observed after 15 min). Acetic acid (0.63 ml) was then added. The resulting DCU was removed by filtration. The filtrate was then evaporated to give 10a (10 g, 100% crude yield).

المصدر