تفاعل #53147

ord-46bbd35b701f44d993e4c75d2ee89958

معادلة التفاعل

$Cl.NCc1ccc(N/C(=C2\C(=O)Nc3ccc([N+](=O)[O-])cc32)c2ccccc2)cc1$

(Z)-3-[1-(4-aminomethyl-phenylamino)-1-phenyl-methylidene]-5-nitro-2-indolinone-hydrochloride

butyraldehyde

sodium cyanoborohydride

→

$CCCCNCc1ccc(N/C(=C2\C(=O)Nc3ccc([N+](=O)[O-])cc32)c2ccccc2)cc1$

(Z)-3-[1-(4-butylaminomethyl-phenylamino)-1-phenyl-methylidene]-5-nitro-2-indolinone

المتفاعلات

$Cl.NCc1ccc(N/C(=C2\C(=O)Nc3ccc([N+](=O)[O-])cc32)c2ccccc2)cc1$

(Z)-3-[1-(4-aminomethyl-phenylamino)-1-phenyl-methylidene]-5-nitro-2-indolinone-hydrochloride

butyraldehyde

sodium cyanoborohydride

الكواشف

لا شيء

المذيبات

methanol

ظروف التفاعل

الظروف التفصيلية

See reaction.notes.procedure_details.

الإجراء التجريبي

Prepared analogously to Example 159 from (Z)-3-[1-(4-aminomethyl-phenylamino)-1-phenyl-methylidene]-5-nitro-2-indolinone-hydrochloride, butyraldehyde and sodium cyanoborohydride in methanol.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US06855710B2uspto-grants-2005_02