تفاعل #531335

معادلة التفاعل

ester

Methyl 11-Morpholinodibenzo[b,f][1,4]thiazepin-3-carboxylate 5,5-Dioxide

potassium hydroxide

water

ethanol

→

title product

11-Morpholinodibenzo[b,f][1,4]thiazepin-3-carboxylic Acid 5,5-Dioxide

المذيبات

dioxane

ظروف التفاعل

المعالجة

1. 1
   أخرىEvaporate to dryness
2. 2
   workup.DISSOLUTIONdissolve the residue in 5 ml of water
3. 3
   أخرىseparate the precipitate
4. 4
   ترشيحby filtration
5. 5
   غسيلwash with water
6. 6
   أخرىdry
7. 7
   أخرىRecrystallize from methanol

الإجراء التجريبي

Stir 386 mg (1 mmole) of the ester of Example 19 in a solution of 131.8 mg (2 mmole) of 85% aqueous potassium hydroxide, 1.3 ml of water, 6.5 ml of ethanol and 0.65 ml of dioxane at room temperature under argon for 1 hour. Evaporate to dryness and dissolve the residue in 5 ml of water. Acidify with acetic acid, separate the precipitate by filtration, wash with water and dry. Recrystallize from methanol to obtain the title product (m.p. 200-295 dec).

المصدر