تفاعل #5313

معادلة التفاعل

4-Methoxybenzeneethanol

1,6-dibromohexane

NaOH

→

oil

1-[2-[(6-Bromohexyl)oxy]ethyl]-4-methoxybenzene

المذيبات

H2O

ظروف التفاعل

المعالجة

1. 1
   استخلاصextracted with ER (3×150 ml)
2. 2
   غسيلthe combined organic extracts were washed consecutively with H2O (125 ml), BR (125 ml)
3. 3
   أخرىdried
4. 4
   أخرىevaporated

الإجراء التجريبي

4-Methoxybenzeneethanol (5.0 g) and 1,6-dibromohexane (23.7 g) were stirred rapidly at RT with tetra-n-butyl ammonium bisulphate (0.94 g) and 12.5 M aqueous NaOH (30 ml) for 16 h. The mixture was diluted with H2O (125 ml), extracted with ER (3×150 ml) and the combined organic extracts were washed consecutively with H2O (125 ml), BR (125 ml), dried and evaporated to give an oil (24.6 g). The oil was purified by [FCS] eluting with ER-CX (0:100→4:96) to give the title compound as a colourless oil (8.30 g). T.l.c. (CX-ER (40:1)) Rf 0.33.

المصدر