تفاعل #531132

معادلة التفاعل

3-hydroxy-3-methyl-4-bromo-5-(4-biphenylyl)-5-pentanolide

tri-n-butyltin hydride

→

desired compound

المردود 51.2%

3-Hydroxy-3-methyl-5-(4-biphenylyl)-5-pentanolide

المردود 51.2%

المذيبات

tetrahydrofuran

ظروف التفاعل

المعالجة

1. 1
   أخرىThe product obtained
2. 2
   أخرىwas recrystallized from a mixture of n-hexane and acetone (10:1)

الإجراء التجريبي

The product obtained by reducing 0.50 g of 3-hydroxy-3-methyl-4-bromo-5-(4-biphenylyl)-5-pentanolide with 1.62 g of tri-n-butyltin hydride in 10 ml of anhydrous tetrahydrofuran according to the method described in Example 2 (a), was recrystallized from a mixture of n-hexane and acetone (10:1) to give 0.20 g of the desired compound melting at 151°-153° C.

المصدر