تفاعل #5310

معادلة التفاعل

Dihydropyran

4-chlorobutanol

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title compound

المردود 89.9%

2-[(4-Chlorobutyl)oxy]tetrahydropyran

المردود 89.9%

ظروف التفاعل

المعالجة

1. 1
   غسيلwashed with H2O (100 ml), aqueous NaHCO3 (1 M, 50 ml) and BR (50 ml)
2. 2
   درجة الحرارةThe dried liquid was heated under reduced pressure

الإجراء التجريبي

Dihydropyran (15.5 g) was added dropwise to a mixture of 4-chlorobutanol (20 g) and hydrochloric acid (18 M, 1 drop) at RT. The mixture was stirred for 30 min and washed with H2O (100 ml), aqueous NaHCO3 (1 M, 50 ml) and BR (50 ml). The dried liquid was heated under reduced pressure to leave the title compound as a colourless liquid (31.9 g). T.l.c. [L] Rf 0.5.

المصدر