تفاعل #530526

معادلة التفاعل

2,6-dimethylaniline

3-hydroxy-2-butanone

→

3-(2,6-dimethylphenylamino)-2-butanone

المردود 94.4%

المذيبات

benzene

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةunder reflux for 21 hours in a reaction vessel
2. 2
   أخرىequipped with a Dean-Stark trap
3. 3
   درجة الحرارةThe reaction mixture was then cooled
4. 4
   غسيلwashed with four 600-ml portions of water
5. 5
   ترشيحfiltered
6. 6
   أخرىevaporated under reduced pressure

الإجراء التجريبي

A solution of 484.8 g (4 mols) 2,6-dimethylaniline and 422.8 g (4.8 mols) 3-hydroxy-2-butanone in 1200 ml benzene was heated under reflux for 21 hours in a reaction vessel equipped with a Dean-Stark trap. The reaction mixture was then cooled, washed with four 600-ml portions of water, slurried with silica gel, filtered and evaporated under reduced pressure to give 722 g of 3-(2,6-dimethylphenylamino)-2-butanone, as an orange oil. The infrared spectrum of the product showed strong carbonyl absorption at 6.3 microns.

المصدر