تفاعل #53031

ord-3a630febe6af458d9394b327ffd67929

معادلة التفاعل

O=C1Nc2ccccc2/C1=C(/Nc1cccc(C(=O)O)c1)c1ccccc1
(Z)-3-[1-(3-carboxyphenylamino)-1-phenyl-methylidene]-2-indolinone
CCOC(=O)CN
glycine ethyl ester
CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F
TBTU
On1nnc2ccccc21
HOBt
→
CCOC(=O)CNC(=O)c1cccc(N/C(=C2\C(=O)Nc3ccccc32)c2ccccc2)c1
(Z)-3-[1-(3-ethoxycarbonylmethylaminocarbonyl-phenylamino)-1-phenyl-methylidene]-2-indolinone

المتفاعلات

O=C1Nc2ccccc2/C1=C(/Nc1cccc(C(=O)O)c1)c1ccccc1
(Z)-3-[1-(3-carboxyphenylamino)-1-phenyl-methylidene]-2-indolinone
CCOC(=O)CN
glycine ethyl ester
CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F
TBTU
On1nnc2ccccc21
HOBt

الكواشف

لا شيء

المذيبات

CN(C)C=O
DMF
CCN(CC)CC
triethylamine

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

الإجراء التجريبي

Prepared analogously to Example 21 from (Z)-3-[1-(3-carboxyphenylamino)-1-phenyl-methylidene]-2-indolinone, glycine ethyl ester, TBTU, HOBt and triethylamine in DMF.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US06855710B2uspto-grants-2005_02