تفاعل #52986
ord-5a5ba54c17ac44b8bce09720bb95188c
معادلة التفاعل
3,5-dimethoxybenzyl alcohol
tert-butyl-diphenylsilyl chloride
imidazole
→
3,5-dimethoxybenzyl tert-butyldiphenylsilyl ether
المردود 87.9%
الكواشف
لا شيء
المذيبات
ظروف التفاعل
الظروف التفصيلية
See reaction.notes.procedure_details.
المعالجة
- 1أخرىDMF was evaporated
- 2أخرىthe residue was purified by column chromatography (silica gel; eluent: hexane to hexane/EtOAc 20% )
الإجراء التجريبي
A mixture of 3,5-dimethoxybenzyl alcohol (4.0 g), tert-butyl-diphenylsilyl chloride (6.54 g) and imidazole (3.28 g) in DMF (60 mL) was stirred at room temperature for 24 h. DMF was evaporated and the residue was purified by column chromatography (silica gel; eluent: hexane to hexane/EtOAc 20% ) to yield 8.5 g of 3,5-dimethoxybenzyl tert-butyldiphenylsilyl ether. ESMS: m/z 407 (MH+).