تفاعل #52983
ord-4b8ebf0f858447abb7f17f0abe7bc319
معادلة التفاعل
3,5-dimethoxybenzyl alcohol
t-butyl-diphenylsilyl chloride
imidazole
→
3,5-dimethoxy-1-[(t-butyldiphenylsilyloxy)methyl]benzene
المردود 87.9%
الكواشف
لا شيء
ظروف التفاعل
الظروف التفصيلية
See reaction.notes.procedure_details.
المعالجة
- 1أخرىDMF was evaporated
- 2أخرىthe residue was purified by column chromatography (silica gel; eluent: hexane to hexane/EtOAc 20%)
الإجراء التجريبي
A mixture of 3,5-dimethoxybenzyl alcohol (4.0 g), t-butyl-diphenylsilyl chloride (6.54 g) and imidazole (3.28 g) in DML (60 mL) was stirred at room temperature for 24 h. DMF was evaporated and the residue was purified by column chromatography (silica gel; eluent: hexane to hexane/EtOAc 20%) to yield 8.5 g of 3,5-dimethoxy-1-[(t-butyldiphenylsilyloxy)methyl]benzene. ESMS: m/z 407 (MH+).