تفاعل #529770

معادلة التفاعل

potassium iodide

4-cyano-4'-hydroxybiphenyl

1-bromodecane

potassium carbonate

→

4-Cyano-4'-decyloxybiphenyl

المذيبات

butanone

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةunder reflux overnight
2. 2
   ترشيحThe cooled solution was filtered
3. 3
   أخرىto remove inorganic salts
4. 4
   أخرىthe solvent was removed in vacuo
5. 5
   workup.DISTILLATIONThe residual oil was distilled
6. 6
   أخرى(to remove excess bromide)
7. 7
   أخرىfinally purified by column chromatography (dichloromethane)
8. 8
   أخرىto yield a colourless,

الإجراء التجريبي

A mixture of 4-cyano-4'-hydroxybiphenyl (56) (10.10 g, 0.052 mol), 1-bromodecane (14.38 g, 0.065 mol), anhydrous potassium carbonate (37.32 g, 0.27 mol), butanone (300 ml) and a trace of potassium iodide was heated under reflux overnight. The cooled solution was filtered to remove inorganic salts and the solvent was removed in vacuo. The residual oil was distilled (to remove excess bromide) and finally purified by column chromatography (dichloromethane) to yield a colourless, low melting solid.

المصدر