تفاعل #529760

معادلة التفاعل

Methyl chloroformate

compound 3

4'-Hydroxy-4-biphenylcarboxylic acid

sodium hydroxide

hydrochloric acid

→

4'-Methoxycarbonyloxy-4-biphenylcarboxylic acid

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONDuring the addition a white precipitate
2. 2
   أخرىwas formed
3. 3
   ترشيحthe resultant voluminous white solid was filtered off
4. 4
   غسيلwashed with water until acid-free and
5. 5
   تجفيفdried (phosphorus pentoxide) in vacuo

الإجراء التجريبي

Methyl chloroformate (12.90 g, 0.137 mol) was added dropwise, over 10 minutes, to a stirred, cooled (5° C.) solution of compound 3 (10.00 g, 0.047 mol) in sodium hydroxide (5.44 g, 0.136 mol) and water (150 ml). During the addition a white precipitate was formed and this stirred mixture was allowed to warm to room temperature overnight. The resultant mixture was carefully acidified (pH 5) with dilute hydrochloric acid and the resultant voluminous white solid was filtered off, washed with water until acid-free and dried (phosphorus pentoxide) in vacuo.

المصدر