تفاعل #528294

معادلة التفاعل

D-glucono-1,5-lactone

glycine dodecyl ester p-toluenesulfonate salt

triethylamine

→

dodecyl glycinate

المردود 61.0%

المذيبات

isopropanol

isopropanol

ظروف التفاعل

المعالجة

1. 1
   أخرىA 100 ml round bottom flask equipped with a condenser, addition funnel
2. 2
   workup.ADDITIONwere added dropwise over 15 minutes from an addition funnel
3. 3
   درجة الحرارةcooled to room temperature
4. 4
   ترشيحThe white product was filtered
5. 5
   غسيلwashed with chloroform (3×150 ml)
6. 6
   أخرىdried under high vacuum at 35° C.

الإجراء التجريبي

A 100 ml round bottom flask equipped with a condenser, addition funnel, thermometer and mechanical stirrer was charged with D-glucono-1,5-lactone (5.0 g, 0.03 mole) and isopropanol (35 g). The suspension was heated to 50° C. over 15 minutes. A mixture of glycine dodecyl ester p-toluenesulfonate salt (11.7 g, 0.03 mole), triethylamine (2.9 g 0.03 mole) and isopropanol (20 g) were added dropwise over 15 minutes from an addition funnel. The reaction mixture was stirred rapidly for about 2 hrs and then cooled to room temperature. The white product was filtered, washed with chloroform (3×150 ml) and dried under high vacuum at 35° C. giving 7.2 g (61% yield) of N-D-gluconyl dodecyl glycinate with a melting point of 121°-122° C. and 98.6% purity.

المصدر