تفاعل #528052

معادلة التفاعل

cyanamide

nitric acid

2-amino-4-nitrotoluene

→

2-methyl-5-nitrophenyl-guanidine nitrate

المذيبات

water

ethanol

ظروف التفاعل

المعالجة

1. 1
   أخرىWhen the exothermic reaction
2. 2
   workup.ADDITIONare added
3. 3
   درجة الحرارةat reflux for 25 hours
4. 4
   درجة الحرارةcooled to 0°
5. 5
   ترشيحfiltered
6. 6
   غسيلWashing with 4×100 mi of ethanol/diethyl ether (1:1)
7. 7
   أخرىdrying

الإجراء التجريبي

9.1 ml (0.13 mol) of 65% nitric acid are added dropwise in the course of 5 minutes to a yellow suspension of 20.0 g (0.13 mol) of 2-amino-4-nitrotoluene in 50 ml of absolute ethanol. When the exothermic reaction has subsided, 8.32 g (0.198 mol) of cyanamide dissolved in 8.3 ml of water are added. The brown reaction mixture is boiled at reflux for 25 hours, cooled to 0° and filtered. Washing with 4×100 mi of ethanol/diethyl ether (1:1) and drying yield 2-methyl-5-nitrophenyl-guanidine nitrate; m.p. 219°-226°.

المصدر