تفاعل #528023

ord-9fa6fa25078c47fea95041c6751b31fd

معادلة التفاعل

CCCc1nc2c(C)cc(NC(=NC#N)N(C)C)cc2n1Cc1ccc(-c2ccccc2C(=O)OC)cc1
methyl 4'-[[2-n-propyl-4-methyl-6-(2-cyano-3,3-dimethyl-guanidino)-1H-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylate
[Na+].[OH-]
sodium hydroxide
→
CCCc1nc2c(C)cc(NC(=NC#N)N(C)C)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1
4'-[[2-n-propyl-4-methyl-6-(2-cyano-3,3-dimethyl-guanidino) -1H-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylic acid

المتفاعلات

CCCc1nc2c(C)cc(NC(=NC#N)N(C)C)cc2n1Cc1ccc(-c2ccccc2C(=O)OC)cc1
methyl 4'-[[2-n-propyl-4-methyl-6-(2-cyano-3,3-dimethyl-guanidino)-1H-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylate
[Na+].[OH-]
sodium hydroxide

الكواشف

لا شيء

المذيبات

CCO
ethanol

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

الإجراء التجريبي

Prepared analogously to Example 1d from methyl 4'-[[2-n-propyl-4-methyl-6-(2-cyano-3,3-dimethyl-guanidino)-1H-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylate and 2N sodium hydroxide solution in ethanol.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US05521177uspto-grants-1996_05