تفاعل #52800

معادلة التفاعل

5-chlorosulfonyl-2-oxindole

isopropylamine

pyridine

→

5-isopropylaminosulfonyl-2-oxindole

المردود 45.5%

المذيبات

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe solid was collected by vacuum filtration
2. 2
   غسيلslurry-washed with hot ethanol
3. 3
   درجة الحرارةcooled
4. 4
   ترشيحcollected by vacuum filtration and vacuum
5. 5
   أخرىdried at 40° C.

الإجراء التجريبي

A suspension of 3 g of 5-chlorosulfonyl-2-oxindole, 1.15 g of isopropylamine and 1.2 mL of pyridine in 50 mL of dichloromethane was stirred at room temperature for 4 hours at which time a white solid was present. The solid was collected by vacuum filtration, slurry-washed with hot ethanol, cooled, collected by vacuum filtration and vacuum dried at 40° C. to give 1.5 g (45%) of 5-isopropylaminosulfonyl-2-oxindole.

المصدر