تفاعل #52642

معادلة التفاعل

4-anisidine

hydrochloric acid

hydroxylamine hydrochloride

chloral hydrate

sodium sulfate

→

N—(2-hydroximinoacetyl)anisidine

المردود 85.2%

المذيبات

water

water

water

ظروف التفاعل

المعالجة

1. 1
   أخرىwas held at 60° C.
2. 2
   workup.ADDITIONThe first solution was then added to the second and the reaction
3. 3
   درجة الحرارةwas refluxed for 2 minutes
4. 4
   درجة الحرارةcooled in an ice bath
5. 5
   أخرىThe tan precipitate which formed
6. 6
   ترشيحwas collected by vacuum filtration
7. 7
   غسيلwashed with water
8. 8
   أخرىdried under vacuum

الإجراء التجريبي

A solution of 11.4 g of hydroxylamine hydrochloride in water (50 ml) was added to a solution of chloral hydrate (9.6 g) and sodium sulfate (83 g) in water (200 ml) at 60° C. The mixture was held at 60° C. while, in a separate flask, a solution of 4-anisidine (6.4 g) and concentrated hydrochloric acid (4.3 ml) in water (80 ml) was warmed to 80° C. The first solution was then added to the second and the reaction was refluxed for 2 minutes, cooled slowly to room temperature and then cooled in an ice bath. The tan precipitate which formed was collected by vacuum filtration, washed with water and dried under vacuum to give 8.6 g (85% yield) of N—(2-hydroximinoacetyl)anisidine.

المصدر