تفاعل #52589

معادلة التفاعل

5-chlorosulfonyl-2-oxindole

methylamine

→

5-methylaminosulfonyl-2-oxindole

المردود 88.0%

المذيبات

tetrahydrofuran

ظروف التفاعل

المعالجة

1. 1
   أخرىformed
2. 2
   ترشيحThe precipitate was collected by vacuum filtration
3. 3
   غسيلwashed twice with 5 mL of water
4. 4
   أخرىdried under vacuum at 40° C. overnight

الإجراء التجريبي

A suspension of 3.38 g of 5-chlorosulfonyl-2-oxindole in 10 mL 2M methylamine in tetrahydrofuran was stirred at room temperature for 4 hours during which time a white solid formed. The precipitate was collected by vacuum filtration, washed twice with 5 mL of water and dried under vacuum at 40° C. overnight to give 3.0 g (88% yield) of 5-methylaminosulfonyl-2-oxindole.

المصدر