تفاعل #52587

معادلة التفاعل

chlorosulfonic acid

2-oxindole

→

5-chlorosulfonyl-2-oxindole

المردود 50.0%

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe reaction temperature was maintained below 30° C. during the addition
2. 2
   workup.ADDITIONAfter the addition
3. 3
   درجة الحرارةheated to 68° C. for 1 hr
4. 4
   درجة الحرارةcooled
5. 5
   غسيلThe precipitate was washed with water
6. 6
   أخرىdried in a vacuum-oven

الإجراء التجريبي

To a 100 mL flask charged with 27 mL of chlorosulfonic acid was added slowly 13.3 g of 2-oxindole. The reaction temperature was maintained below 30° C. during the addition. After the addition, the reaction mixture was stirred at room temperature for 1.5 hr, heated to 68° C. for 1 hr, cooled, and poured into water. The precipitate was washed with water and dried in a vacuum-oven to give 11.0 g of 5-chlorosulfonyl-2-oxindole (50% yield) which was used without further purification.

المصدر