تفاعل #5251

معادلة التفاعل

1-ethoxycarbonyl-4-hydroxy-4-(3,4-dichlorophenyl)piperidine

KOH

→

compound

المردود 90.0%

4-Hydroxy-4-(3,4-dichlorophenyl)piperidine

المردود 90.0%

المذيبات

nBuOH

ظروف التفاعل

المعالجة

1. 1
   أخرىevaporated
2. 2
   تركيزThe reaction mixture is concentrated under reduced pressure
3. 3
   استخلاصextracted with ethyl acetate
4. 4
   غسيلThe organic layer is washed with water
5. 5
   أخرىdried
6. 6
   أخرىevaporated
7. 7
   أخرىThe resulting crystalline residue is recrystallized from ethyl acetate

الإجراء التجريبي

A mixture of 64.2 g of 1-ethoxycarbonyl-4-hydroxy-4-(3,4-dichlorophenyl)piperidine (X-1) and a solution of 72.4 g of KOH in 700 ml of nBuOH is refluxed for 2 hours and evaporated. The reaction mixture is concentrated under reduced pressure and extracted with ethyl acetate. The organic layer is washed with water, dried and evaporated. The resulting crystalline residue is recrystallized from ethyl acetate to prepare 44.7 g (Yield: 90.0%) of the compound (II-1). mp. 144.5°-146.0° C.

المصدر