تفاعل #52482

معادلة التفاعل

tert-butyl [1-(4-bromophenyl)-cyclopropyl]-carbamate

Intermediate 115

tert-butyl [1-(4-bromophenyl)-cyclopropyl]-carbamate

HCl

→

1-(4-Bromophenyl)-cyclopropylamine

المذيبات

MeOH

THF

ظروف التفاعل

المعالجة

1. 1
   أخرىThe reaction was quenched
2. 2
   استخلاصThe mixture was extracted with Et2O
3. 3
   غسيلthe combined organic layers were washed with H2O and saturated aqueous NaCl
4. 4
   تجفيفbefore being dried (MgSO4)
5. 5
   تركيزconcentrated under reduced pressure
6. 6
   أخرىThe title compound 613 mg (85%) was used without further purification

الإجراء التجريبي

To a solution of tert-butyl [1-(4-bromophenyl)-cyclopropyl]-carbamate (Intermediate 115, 1.08 g, 3.40 mmols) in 20 mL MeOH and 20 mL THF was added 20 mL of 3M aqueous HCl. The solution was warmed to 35° C. for 3 hours and then stirred for 17 h at 25° C. The reaction was quenched by adjusting the pH of the solution to 12 with 3M aqueous NaOH. The mixture was extracted with Et2O and the combined organic layers were washed with H2O and saturated aqueous NaCl before being dried (MgSO4) and concentrated under reduced pressure. The title compound 613 mg (85%) was used without further purification.

المصدر