تفاعل #52447

معادلة التفاعل

2,2-dimethylpropanol

2-methyl-4-bromo-benzoic acid

pyridine

→

title compound

المردود 68.0%

2,2-Dimethylpropyl 2-methyl-4-bromobenzoate

المردود 68.0%

المذيبات

SOCl2

ظروف التفاعل

المعالجة

1. 1
   تركيزThe resulting solution was concentrated under reduced pressure

الإجراء التجريبي

Using General Esterification Method C; 2-methyl-4-bromo-benzoic acid (1.82 g, 8.47 mmols) was refluxed for 3 h with 10 mL SOCl2. The resulting solution was concentrated under reduced pressure and the crude acyl chloride combined with 2,2-dimethylpropanol (0.75 g, 8.47 mmols) and pyridine (1.4 mL, 16.9 mmols) to give the title compound (1.64 g, 68%) after work-up and column chromatography (2-5% EtOAc—hexanes) as a colorless oil.

المصدر