تفاعل #52378

معادلة التفاعل

8-cyclopropyl-6-ethynyl-2,2,4,4-tetramethylchroman

triethyl amine

ethyl-4-iodo-benzoate

Reagent A

ethyl-4-iodo-benzoate

tetrahydrofuran

Intermediate 34

8-cyclopropyl-6-ethynyl-2,2,4,4-tetramethylchroman

→

title compound

4-(8-Cyclopropyl-2,2,4,4-tetramethyl-chroman-6-yl-ethynyl)-benzoic acid ethyl ester

المذيبات

ethyl acetate

hexane

ظروف التفاعل

الإجراء التجريبي

Following general procedure F and using 8-cyclopropyl-6-ethynyl-2,2,4,4-tetramethylchroman (Intermediate 34, 0.1 g, 0.38 mmol), ethyl-4-iodo-benzoate (Reagent A, 0.1 g, 0.34 mmol), triethyl amine (5 mL), tetrahydrofuran(10 mL), copper(I)iodide(0.025 g, 0.13 mmol) and dichlorobis(triphenylphosphine)palladium(II) (0.075 g, 0.11 mmol) followed by flash column chromatography over silica gel (230-400 mesh) using 5-10% ethyl acetate in hexane as the eluent, the title compound was obtained (0.135 g, 89%).

المصدر