تفاعل #52366

معادلة التفاعل

6-ethynyl-2,2,4,4-tetramethylchroman

tetrahydrofuran

Reagent G

methyl-2-fluoro-4-iodo-benzoate

triethyl amine

methyl-2-fluoro-4-iodo-benzoate

→

title compound

2-Fluoro-4-(2,2,4,4-tetramethyl-chroman-6-yl-ethynyl)-benzoic acid methyl ester

المذيبات

hexane

ethyl acetate

ظروف التفاعل

الإجراء التجريبي

Following general procedure F and using 6-ethynyl-2,2,4,4-tetramethylchroman (0.11 g, 0.51 mmol), methyl-2-fluoro-4-iodo-benzoate (Reagent G, 0.14 g, 0.51 mmol), triethyl amine (5 mL), tetrahydrofuran(10 mL), copper(I)iodide(0.030 g, 0.16 mmol) and dichlorobis(triphenylphosphine)palladium(II) (0.110 g, 0.16 mmol) followed by flash column chromatography over silica gel (230-400 mesh) using 5-10% ethyl acetate in hexane as the eluent, the title compound was obtained (0.14 g, 79%).

المصدر