تفاعل #52247

معادلة التفاعل

Hydroxy ethylmaleimide

isophorone diisocyanate

→

Isophorone Bisurethane Bisethylmaleimide

المذيبات

acetone

ظروف التفاعل

المعالجة

1. 1
   أخرىpurged with nitrogen
2. 2
   workup.ADDITIONOne drop of dibutyl tin dilaurate was added to the solution
3. 3
   workup.STIRRINGto stir overnight
4. 4
   أخرىa white precipitate was obtained
5. 5
   أخرىafter solvent removal m.p. 105-112° C. (40.5 g, 100%)

الإجراء التجريبي

Hydroxy ethylmaleimide (10 g, 0.141 mol) was dissolved in acetone and purged with nitrogen while stirring in an ice bath. One drop of dibutyl tin dilaurate was added to the solution. The isophorone diisocyanate (30.5 g, 0.141 mol) was added dropwise over 2-3 hours. The solution was allowed to stir overnight and a white precipitate was obtained after solvent removal m.p. 105-112° C. (40.5 g, 100%). 1H-NMR (D6-DMSO, δ, ppm): 3.63-3.58 (2H, —NCH2—), 4.08-4.03 (2H, —CH2O—, t), 7.03 (2H, —CH═CH—, s). 13C-NMR (D6-DMSO, δ, ppm): 134.5 (2C, —CH═CH—), 154.9 (2C, NHC═O), (170.7 (2C, —NC═O).

المصدر