تفاعل #52240

معادلة التفاعل

imidazo[1,2-a]pyrimidine-2-carboxylate

KOH

→

tan solid

المردود 83.0%

Imidazo[1,2-a]pyrimidine-2-carboxylic acid

المردود 83.0%

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe solution was heated to reflux
2. 2
   أخرىthe heating mantle was removed
3. 3
   درجة الحرارةto cool
4. 4
   أخرىthe solvent was removed by rotary evaporation
5. 5
   workup.DISSOLUTIONThe residue was dissolved in water (20 mL)
6. 6
   ترشيحThe resulting precipitate was filtered
7. 7
   غسيلwashed with water
8. 8
   أخرىdried in vacuo

الإجراء التجريبي

To a stirring solution of ethyl 1-(imidazo[1,2-a]pyrimidine-2-carboxylate (1 g, 5.2 mmol) [Abignente, et al. Eur. J. Med. Chem. (1994) 29, 279] in ethanol (30 mL) was added 2 N aqueous KOH (10 mL, 20 mmol). The solution was heated to reflux; and after 2 h, the heating mantle was removed, the solution was allowed to cool and the solvent was removed by rotary evaporation. The residue was dissolved in water (20 mL) and acidified to pH 3 with 5 N HCl. The resulting precipitate was filtered, washed with water and dried in vacuo to give 700 mg (83%) of a tan solid.

المصدر