تفاعل #52236

معادلة التفاعل

1-Boc-isonipecotic acid

BH3-THF

→

l-Boc-piperidine-4-methanol

المردود 85.0%

المذيبات

THF

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةto warm to room temperature for 12 h
2. 2
   أخرىThe mixture was carefully quenched with water
3. 3
   workup.ADDITIONdiluted with ethyl acetate
4. 4
   استخلاصThe water layer was extracted with ethyl acetate
5. 5
   غسيلwashed with brine
6. 6
   تجفيفdried (Na2SO4)
7. 7
   ترشيحfiltered
8. 8
   تركيزconcentrated

الإجراء التجريبي

1-Boc-isonipecotic acid (10.0 g, 214 mmol) was dissolved in THF (400 mL) and cooled to 0° C. A solution of BH3-THF (180 mL, 1 N in THF, 180 mmol) was added slowly. The mixture stirred for 1 h at 0° C. and was allowed to warm to room temperature for 12 h. The mixture was carefully quenched with water and diluted with ethyl acetate. The water layer was extracted with ethyl acetate. The organic layers were combined, washed with brine, dried (Na2SO4), filtered and concentrated to provide l-Boc-piperidine-4-methanol (7.98 g, 85%) as a white solid.

المصدر