تفاعل #52178

معادلة التفاعل

3,9-dimethylbenzo[f]quinazolin-1(2H)-one

N-bromo-succinimide

→

9-bromomethyl-3-methylbenzo[f]quinazolin-1(2H)-one

المردود 83.0%

المذيبات

benzene

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةbelow reflux for 30 minutes
2. 2
   درجة الحرارةat a gentle reflux for 30 minutes
3. 3
   درجة الحرارةto cool for 2 hours
4. 4
   ترشيحthe solid filtered
5. 5
   أخرىdried at 70° C. under reduced pressure

الإجراء التجريبي

To a hot solution of 3,9-dimethylbenzo[f]quinazolin-1(2H)-one (4.00 g, 17.9 mmol) in benzene (2000 ml) under nitrogen was added N-bromo-succinimide (4.00 g, 22.5 mmol). The reaction mixture was stirred just below reflux for 30 minutes, then at a gentle reflux for 30 minutes. The resulting suspension was allowed to cool for 2 hours, the solid filtered and dried at 70° C. under reduced pressure to give 9-bromomethyl-3-methylbenzo[f]quinazolin-1(2H)-one (4.32 g, 83% purify by NMR).

المصدر